OVERVIEW

Our lab attempts to understand underlying mechanisms of disease via a detailed molecular comparison to the normal state. We develop and use technologies within the field of single-cell genomics and proteomics. Our goal is to study the inner workings of complex cellular ecosystems at single cell resolution and eventually understand the spatial and temporal differences of health and disease. 

Our work on: i) the heterogeneity and developmental origins of human melanocytes and the comparison to melanoma, ii) the effects of Chloride regulation in the development of the conducting airway , iii) the different modes of resistance of primary human lung cancers as well as iv) the study of aging across an entire organism are examples of current ongoing efforts towards this goal.